UNIVERSITA' DEGLI STUDI DI BARI

 

 

Antonio Salomone
Dipartimento Farmaco Chimico
Università di Bari
Via E. Orabona, 4
I-70125 Bari (Italy).
Tel: +39.080.5442773
Fax: +39.080.5442539
 E-mail: antoniosalomone@libero.it

 

 

Personal information:

DATE OF BIRTH: july 29th 1974
PLACE OF BIRTH: Taranto (Italy)
CITIZENSHIP: Italian

Education:

University of Bari, Faculty of Pharmacy, Italy
BS cum laude, Pharmaceutical Chemistry and Technology
November 1999, Thesis advisor: Prof. Saverio Florio.

Skills:

- Proficient user of ¹H and ¹³C FT-NMR, FT-IR, UV-vis spectrometer, GC-MS, analytical and preparative HPLC.
- Experencied in analytical chemistry and synthetic organic chemistry.
- languages: Italian and English.

Professional Experience:

1999 - Thesis in Organic Chemistry with Prof. Saverio Florio at University of Bari. Synthesis of trisubstituted oxazolinyloxiranes via deprotonation of oxazolinyl oxirane; (publication).

2003 - PhD in Pharmaceutical Chemistry. Thesis: “α-Lithiated phenyl epoxides: new intermediates in the asimmetric synthesis of drugs”
Thesis advisor: Prof. Saverio Florio

 

 

Research Activity:

- Asymmetric synthesis of of enantiopure "building blocks" for organic and pharmaceutical synthesis.

 

 

- Stereocontrolled Synthesis of Functionalized Cyclic Molecules from alfa- and ortho-Lithiated Aryloxiranes

 

- Mechanisms of Racemization of Chiral Organolithiums

DH^≠ = 5.45 kcal/mol ; DS^≠ = - 43.9 cal/ mol·K

 

 - Spectroscopic Characterization of Oxiranyllithiums by ¹H-, ⁷Li-, ¹³C- and ¹⁹F-NMR

 

 

 

 

 

Schools and Courses:

1) “XXI Advanced School on Pharmacetical Chemistry for PhD students “E. Duranti”
     Urbino (Italy), 1-5 July 2000.

2) “Seminars in Organic Synthesis - XXVI Summer School A. Corbella”
     Gargnano (Italy), June 11-15 2001;

3) “Winter School on Physical Organic Chemistry”
     Bressanone (Italy), (11/01/07 – 18/01/07)

 

 

Conference Participation and Contributions:

- XXVII Convegno Nazionale della Divisione di Chimica Organica, Trieste. (3/09/01 – 7/09/01)
Poster presentation:“Deprotonazione stereospecifica di stirenossidi: sintesi di epossidi otticamente puri”

- Riunione Scientifica della Società Chimica Italiana, Sezione Puglia – 2004 – “La chimica per la qualità della vita”, Bari. (17/12/2004)
Oral Presentation: “Synthetic utility of lithiated stilbene oxides”

- XX International Colloquium on Heterocyclic Chemistry, Palermo (31/07/05 – 5/08/05)
Poster Presentation: “Ortho-Lithiated Aryloxiranes in the Stereoselective Synthesis of Phthalanes”

- XXX Convegno Nazionale della Divisione di Chimica Organica, Siena (19/09/05 – 23/09/05)
Oral Presentation: “Arilossirani orto-litiati nella sintesi stereospecifica di tetraidronaftoli”

- The 10^th RSC – SCI Joint Meeting on Heterocyclic Chemistry, Harrogate – UK (09/06/06 – 12/06/06)
Oral Presentation: “Asymmetric Synthesis of 1,2-Oxazetidines from a-Lithiated Aryloxiranes”

- XXII European Colloquium on Heterocyclic Chemistry, Bari (02/09/06 – 06/09/06)
Poster Presentation:  “Highly Stereoselective Synthesis of 4-Hydroxyalkyl-1,2-Oxazetidines from a-Lithiated Aryloxiranes”

- XXXI Convegno Nazionale della Divisione di Chimica Organica della Società Chimica Italiana Rende, (10/09/07 – 14/10/07)
Poster Presentation: “Addizione di Arilossirani orto-Litiati a Benzilidenemalonati: una Reazione Domino per la Sintesi di Tetraidroindenofuranoni”

- 7th Spanish-Italian Symposium on Organic Chemistry (SISOC-7), Oviedo-Spain (07/09/08-10/09/08)
Oral Presentation: “Ortho-Lithiated Epoxides Based Synthesis of Tetrahydroindenofuranones“

- 9^a Giornata Scientifica Borsisti C.I.N.M.P.I.S. – Padova (2/09/2009)
Oral Presentation: “On the Configurational Stability of a-Lithiated Aryloxiranes“

- 24^th International Symposium on the Organic Chemistry of Sulfur (ISOCS 24) – Firenze (25/07/10 – 30/07/10)
Oral Presentation: “On the Configurational Stability of a-Lithiated Sulfurated Styrene Oxides: Synthetic and Mechanistic Aspects”

 

 

Publications:

1)  V. Capriati, S. Florio, R. Luisi, V. Russo and A. Salomone

     “Oxiranyllithium Based Synthesis of a-Keto-2-Oxazolines”, 

 

     Tetrahedron Lett. 2000, 41, 8835–8838.

 

 

2)  A. Abbotto, V. Capriati, L. Degennaro, S. Florio, R. Luisi, M. Pierrot and A. Salomone

     "A Stereospecific Synthesis of Oxazolinyloxiranes" 

 

     J. Org. Chem. 2001, 66, 3049–3058.

 

 

3) Vito Capriati, Saverio Florio, Renzo Luisi and Antonio Salomone

 

     "Oxiranyl Anion-Mediated Synthesis of Highly Enantiomerically Enriched Styrene Oxide Derivatives"

 

     Org. Lett. 2002, 4 (14), 2445-2448.

 

 

4)  Saverio Florio, Varinder Aggarwal, Antonio Salomone

 

      "Lithiation and Reactions of Stilbene Oxides: Synthetic Utility"

 

     Organic Letters, 2004, 6,4191-4194.

 

 

5)  Vito Capriati, Saverio Florio, Renzo Luisi, Filippo Maria Perna, Antonio Salomone, and Francesco Gasparrini

 

      "An Efficient Route to Tetrahydronaphthols via Addition of Ortho-Lithiated Stilbene Oxides to a,b-Unsatured Fischer Carbene Complexes."

 

      Organic Letters 2005, 7, 4895-4898.

 

 

6)  Vito Capriati, Saverio Florio, Renzo Luisi, Filippo M. Perna, and Antonio Salomone

 

     "Synthesis of 1,3-Dihydrobenzo [c] furans from Ortho-Lithiated Aryloxiranes"

 

     J. Org. Chem. 2006, 70, 3984-3987.

 

 

7)  Vito Capriati , Saverio Florio, Renzo Luisi, Antonio Salomone, Corrado Cuocci

 

    "Stereoselective Synthesis of Novel b,g-Epoxyhydroxylamines and 4-Hydroxyalkyl-1,2-Oxazetidines”

 

    Org. Lett. 2006, 8 (18), 3923–3926.

 

 

8)  Vito Capriati , Saverio Florio, Renzo Luisi, Antonio Salomone, Corrado Cuocci

 

    "Crystal structure of (N-tert-butyl-3,4-diphenyl-1,2-oxazetidin-4-yl) methanol, C₁₉H₂₃NO₂”

 

    Z. Kristallogr. NCS 2006, 221, 1-3.

 

 

9)  Vito Capriati , Saverio Florio, Renzo Luisi, Antonio Salomone

 

    "Michael Addition of Ortho-Lithiated Aryloxiranes to a,b-Unsaturated Malonates: Synthesis of Tetrahydroindenofuranones”

 

    Organic Letters 2008, 10, 1947.

 

 

10)  Vito Capriati , Saverio Florio, Renzo Luisi, Antonio Salomone, Maria Giovanna Tocco, Ana Martin Castro, Josè Luis Garcia Ruano, Esther Torrente

 

    "Influence of an ortho-sulfinyl group on the configurational stability of a-lithiated aryloxiranes: deuteration of tolylsulfinyl styrene oxides”

 

    Tetrahedron 2009, 65, 383.

 

 

11)  Vito Capriati , Saverio Florio, Antonio Salomone, Alessandro Abbotto, Mohamed Amedjkouh, Sten O. Nilsson Lill

 

    "On the Dichotomic Reactivity of Lithiated Styrene Oxide: A Computational and Multinuclear Magnetic Resonance Investigation”

 

    Chem. Eur. J. 2009, 15, 7958 – 7979.

 

 

12)  Vito Capriati , Saverio Florio, Antonio Salomone

 

     Chapter 4: "Oxiranyllithiums as Chiral Synthons for Asymmetric Synthesis in Stereochemical Aspects of Organolithium Compounds"

 

    p135-164, Verlag Helvetica Chimica Acta, Zurich 26: Topics in Sterochemistry R. E. Gawley, J. S. Siegel

 

 

13) Vito Capriati, Saverio Florio, Filippo Maria Perna, Antonio Salomone

 

    "Lithiated Fluorinated Styrene Oxides: Configurational Stabiity, Synthetic Applications, and Mechanistic Insights"

 

    Chem. Eur. J. 2010, 16, 9778 – 9788

 

 

14) Vito Capriati, Saverio Florio, Filippo Maria Perna, Antonio Salomone

 

    "On the Configurational Stability of α-Lithiated Sulfurated Styrene Oxides: Sybthetic and Mechanistic Aspects”

 

    Phosphorus, Sulfur, and Silicon and the Related Elements “in press”