UNIVERSITA' DEGLI STUDI DI BARI
Leonardo
Degennaro
Dipartimento Farmaco Chimico
Università di Bari
Via E. Orabona, 4
I-70125 Bari (Italy).
Tel: +39.080.5442773
Fax: +39.080.5442539
E-mail: ldegennaro@farmchim.uniba.it
Personal information:
DATE OF BIRTH:
July 04th 1972
PLACE OF BIRTH: Bitonto (Italy)
CITIZENSHIP: Italian
Education:
University
of Bari, Pharmaceutical-Chemistry Department, Italy
Ph. D.Student, II year, Chemical and Enzymatic applied Synthesis
Thesis advisor: Prof. Saverio Florio.
University
of Bari, Faculty of Pharmacy, Italy
BS 107/110, Pharmaceutical Chemistry and Technology
July 1999,
Thesis advisor: Prof. Saverio Florio.
Professional Experience:
University of Bari, Faculty of Pharmacy, Italy
Teaching activities concerning the courses organic chemistry for undergraduate
students of the degrees in Pharmacy: frontal lessons and exercises in the
classroom (aa 2008-2010).
In Organic Chemistry for the degree course in Drug Scientific information:
support lessons and exercises in the classroom (aa 2006-2007 and 2007-2008).
In Physical Methods in Organic Chemistry for the degree course in Chemistry and
Pharmaceutical Technology: exercises in the classroom (aa 2006-2007).
University of Groningen, Faculty of Chemistry, Netherlands
March 2002 – October 2002: PhD collaboration with Prof. Feringa’s group on
“Catalytic asymmetric addition of organozinc reagents to unsaturated compounds”.
University of Bari, Pharmaceutical-Chemistry Department, Italy
September 1999 - December 1999: Fellowship by Pharmaceutics-chemistry Department
–University of Bari – with Prof. S. Florio. Field of interest: “Reactivity of
functionalizated oxiranes”.
University of Bari, Pharmaceutical-Chemistry Department, Italy
Winter 1996 - Winter 1998: Thesis research in Organic Chemistry with Prof.
Saverio Florio at University of Bari. “Synthesis and reactivity of optically
actives 2-chloroalkyloxazolines”.
Winter 1999 - Winter 2000 Obbligatory National Service in the Italian Army as
Artillery soldier.
Research Activity:
It is concerning asymmetric synthesis and structural characterization of heterocyclic compounds and amino acid derivatives by using organometallic species, copper-phosphoramidites catalysts and oxazolines chemistry, understanding reactions mechanism to bring the results of research towards useful applications in biological, drugs, new materials, catalyst fields.
Schools and Courses:
• Terzo Simposio Italo-Tedesco in Chimica Organica, 30 marzo – 1 Aprile, 2001,
Ravenna. Presentazione Poster: “Nucleofilic Addition of Lithiated Alkyl and
Chloroalkyloxazolines to Nitrones”.
• XXVII Convegno Nazionale della Divisione di Chimica Organica, Trieste, 3-7
settembre 2001. Presentazione Poster: “Sintesi Stereoselettiva di
Ossazolinilstireni”.
• XXVI Corso Estivo “ A. Corbella”, 18-22 giugno 2001, Gargnano.
• “Riunione Scientifica Della Sezione Puglia –2002- I Giovani e la Ricerca
Chimica in Puglia”, 16-17 Dicembre 2002, Dipartimento di chimica, Bari.
• XXI Congresso Nazionale della Società Chimica Italiana, Torino, 22-27 giugno
2003. Presentazione Poster: “Sintesi di nuovi eterocicli spiro precursori di
-epossi--amminoacidi”.
• Meeting dei ricercatori afferenti al progetto di ricerca di interesse
nazionale cofinanziato dal M.I.U.R.: “Stereoselezione in Sintesi Organica:
Metodologie ed Applicazioni”, Camerino, 27-28 febbraio 2003. Presentazione
orale: “Sintesi di nuovi eterocicli spiro precursori di -epossi--amminoacidi”.
• Giornata di studio “NMR in Puglia: ambiente, salute” tenuta a Bari, 1 giugno
2001, organizzata dal consorzio C.I.R.C.M.S.B.
• “IX Joint Meeting on Heterocyclic Chemistry”, Urbino, 5-9 maggio 2004.
Presentazione poster: -Lithiated Oxazolinyloxiranes for the Stereoselective
Synthesis of 4,5-Epoxy-1,2-oxazin-6-ones”.
• “5th Spanish-Italian Symposium on Organic Chemistry (SISOC-5)”, Santiago de
Compostela , 10-13 settembre 2004. Presentazione poster: “Stereoselective
Synthesis of 4,5-Epoxy-1,2-oxazin-6-ones via Reaction of -Lithiated
Oxazolinyloxiranes and Nitrones”.
• “Ischia Advanced School of Organic Chemistry”, Ischia, 18-23 settembre 2004.
Presentazione poster: “-Aryl-Substituted Oxazolinyloxiranyllithiums-Mediated
Stereoselective Synthesis of 4,5-Epoxy-1,2-oxazin-6-ones”.
• “Riunione Scientifica della Sezione Puglia- 2004 – La chimica per la qualità
della vita”, Bari, 16-17 dicembre 2004. Presentazione orale: “Stereoselective
Synthesis of 4,5-Epoxy-1,2-Oxazin-6-ones via Reaction of -Lithiated
Oxazolinyloxiranes with Nitrones”.
• “First Austrian-German-Italian Meeting of Organic Chemistry”, Vienna, 1-2
aprile 2005. Presentazione poster: “On the Addition of Lithiated Alkyloxazolines
with Nitrones”.
• XXII Eupopean Colloqium on Heterocyclic Chemistry, Bari, 2-6 Settembre 2006.
Presentazione poster: “On the Addition of Lithiated Alkyloxazolines to Nitrones”.
• XXXII Convegno Nazionale della Divisione di Chimica Organica, Taormina, 26-30
Luglio 2008. Presentazione Orale: “Sintesi Stereoselettiva di Nuovi Derivati
2,2,3-Amminoacidici non Naturali.
Publications:
1) Saverio Florio, Vito Capriati, Renzo Luisi, Leonardo Degennaro
A highly stereoselective synthesis of a,b-unsaturated oxazolines
Tetrahedron Lett. 2001, 42, 9183-9186.
2) Saverio Florio, Vito Capriati, Renzo Luisi, Alessandro Abbotto,
Leonardo Degennaro and Antonio Salomone
A stereospecific: Synthesis of
Oxazolinyloxiranes
J. Org. Chem. 2001, 66, 3049-3058.
3) Saverio Florio, Vito Capriati, Renzo Luisi, Leonardo Degennaro,
Carmela Tralli, Luigino Troisi
Lithiation of 2-(1-Chloroethyl)-2-oxazolines: Synthesis of substituted oxazolinyloxiranes and oxazolinylaziridines.
Synthesis. 2001, 15, 2299-2306.
4) Vito Capriati, Leonardo Degennaro, Saverio Florio, and Renzo Luisi
“On the Addition of Lithiated 2-Alkyl- and 2-(Chloroalkyl)-4,5-dihydro-1,3-oxazoles to Nitrones – A Mechanistic Investigation”
Eur. J. Org. Chem. 2002, 2961-2969.
5) Vito Capriati, Leonardo Degennaro, Raffaele Favia, Saverio Florio and Renzo Luisi
"Stereospecific b-lithiation of oxazolinyloxiranes: Synthesis of a,b-epoxy-g-butyrolactones"
Org. Lett. 2002, 1551-1554.
6) Renzo Luisi, Vito Capriati, Leonardo Degennaro, Saverio Florio
“Oxazolinyloxiranyllithium-Mediated Stereoselective Synthesis of
a-Epoxy-b-Amino Acids”
Org. Lett. 2003, 5 (15) 2723–2726.
7) Renzo Luisi, Vito Capriati, Claudia Carlucci, Leonardo Degennaro, Saverio Florio
“Lithiation of Optically Active Oxazolinyloxiranes: Configurational Stability”
Tetrahedron 2003, 59, 9707–9712.
8) Renzo Luisi, Vito Capriati, Leonardo Degennaro, Saverio Florio
“Oxazolinyloxiranyllithium-Mediated Synthesis of Highly Strained Hetrocyclic
Compounds”
Tetrahedron 2003, 59, 9713–9718
9) Saverio Florio, Vito Capriati, Leonardo Degennaro, Renzo Luisi, Filippo Maria Perna
"Novel oxazoline-mediated Syntheses of heterocycles" Oxygen-and Sulfur-Containing Heterocycles, The Chemistry and Biological Activity of Synthetic and Natural Compounds, IBS Press, 2003, Vol 1, 66.
10)
Vito Capriati
, Leonardo Degennaro, Saverio Florio, Renzo Luisi, Pasqualina Punzi
“Stereoselective
Synthesis of Novel 4,5-Epoxy-1,2-oxazin-6-ones and a,b-Epoxy-g-amino
Acids from b-Lithiated Oxazolinyloxiranes and
Nitrones”
11) Vito Capriati , Leonardo Degennaro, Saverio Florio and Renzo Luisi
"Oxazoline-mediated highly stereoselective synthesis of a,b-substituted-b-aminoalkanamides, potential precursors of unnatural b2,2,3-amino acids"
Tetrahedron Letters 2007,48, 8651-8658.
12) Vito Capriati , Leonardo Degennaro, Saverio Florio, Renzo Luisi and Corrado Cuocci
"Asymmetric synthesis of a,b-substituted b-aminoalkanamides and stereochemical determination"
Tetrahedron Letters 2007,48, 8655-8658.
13) Capriati V., Degennaro L., Forio S., Luisi R., Moliterni A. and Rizzi R.. “Crystal structure of (2R*,3R*)-3-amino-2-ethyl-N-(2-hydroxy-1,1-dimethylethyl)-3-p-methoxyphenylpropanamide, C17H28N2O3”. Zeitschift Fur Kristallographie, 2008, vol. 223; p. 483-484, ISSN: 0044-2968
14) Capriati V., Degennaro L., Forio S., Luisi R., Cuocci C. and Campi G. . “Crystal Structure of (+)-(2S,3S,1’S)-2-Ethyl-N-(1-Hydroxymethyl-2-Methylpropyl)-2-Methyl-3-Phenyl-3-Phenylamino Propanamide, C23H32N2O2”. Zeitschift Fur Kristallographie, 2008, vol. 223; p. 481-482, ISSN: 0044-2968
15) Degennaro L., Capriati V., Carlucci C., Florio S., Luisi R., Nuzzo I., Cuocci C.. Terminal Oxazolinyloxiranes: Synthesis, Reaction with Amines and Regioselective β-Lithiation. Tetrahedron, 2009, vol. 65; p. 8745-8755, ISSN: 0040-4020, doi: 10.1016/j.tet.2009.08.040
16) Dammacco M., Degennaro L., Florio S., Luisi R., Musio B. and Altomare A.. Lithiation of N-Alkyl-(o-tolyl)aziridine: Stereoselective Synthesis of Isochromans. Journal of Organic Chemistry, 2009, vol. 74; p. 6319-6322, ISSN: 0022-3263, doi: 10.1021/jo9011943