UNIVERSITA' DEGLI STUDI DI BARI

 

Leonardo Degennaro
Dipartimento Farmaco Chimico
Università di Bari
Via E. Orabona, 4
I-70125 Bari (Italy).
Tel: +39.080.5442773
Fax: +39.080.5442539
E-mail: ldegennaro@farmchim.uniba.it

 

Personal information:

DATE OF BIRTH: July 04th 1972
PLACE OF BIRTH: Bitonto (Italy)
CITIZENSHIP: Italian

Education:

University of Bari, Pharmaceutical-Chemistry Department, Italy
Ph. D.Student, II year, Chemical and Enzymatic applied Synthesis
Thesis advisor: Prof. Saverio Florio.

University of Bari, Faculty of Pharmacy, Italy
BS 107/110, Pharmaceutical Chemistry and Technology
July 1999, Thesis advisor: Prof. Saverio Florio.

Professional Experience:

University of Bari, Faculty of Pharmacy, Italy
Teaching activities concerning the courses organic chemistry for undergraduate students of the degrees in Pharmacy: frontal lessons and exercises in the classroom (aa 2008-2010).
In Organic Chemistry for the degree course in Drug Scientific information: support lessons and exercises in the classroom (aa 2006-2007 and 2007-2008).
In Physical Methods in Organic Chemistry for the degree course in Chemistry and Pharmaceutical Technology: exercises in the classroom (aa 2006-2007).

University of Groningen, Faculty of Chemistry, Netherlands
March 2002 – October 2002: PhD collaboration with Prof. Feringa’s group on “Catalytic asymmetric addition of organozinc reagents to unsaturated compounds”.

University of Bari, Pharmaceutical-Chemistry Department, Italy
September 1999 - December 1999: Fellowship by Pharmaceutics-chemistry Department –University of Bari – with Prof. S. Florio. Field of interest: “Reactivity of functionalizated oxiranes”.

University of Bari, Pharmaceutical-Chemistry Department, Italy
Winter 1996 - Winter 1998: Thesis research in Organic Chemistry with Prof. Saverio Florio at University of Bari. “Synthesis and reactivity of optically actives 2-chloroalkyloxazolines”.

Winter 1999 - Winter 2000 Obbligatory National Service in the Italian Army as Artillery soldier.

Research Activity:

It is concerning asymmetric synthesis and structural characterization of heterocyclic compounds and amino acid derivatives by using organometallic species, copper-phosphoramidites catalysts and oxazolines chemistry, understanding reactions mechanism to bring the results of research towards useful applications in biological, drugs, new materials, catalyst fields.

Schools and Courses:

• Terzo Simposio Italo-Tedesco in Chimica Organica, 30 marzo – 1 Aprile, 2001, Ravenna. Presentazione Poster: “Nucleofilic Addition of Lithiated Alkyl and Chloroalkyloxazolines to Nitrones”.

• XXVII Convegno Nazionale della Divisione di Chimica Organica, Trieste, 3-7 settembre 2001. Presentazione Poster: “Sintesi Stereoselettiva di Ossazolinilstireni”.

• XXVI Corso Estivo “ A. Corbella”, 18-22 giugno 2001, Gargnano.

• “Riunione Scientifica Della Sezione Puglia –2002- I Giovani e la Ricerca Chimica in Puglia”, 16-17 Dicembre 2002, Dipartimento di chimica, Bari.

• XXI Congresso Nazionale della Società Chimica Italiana, Torino, 22-27 giugno 2003. Presentazione Poster: “Sintesi di nuovi eterocicli spiro precursori di -epossi--amminoacidi”.

• Meeting dei ricercatori afferenti al progetto di ricerca di interesse nazionale cofinanziato dal M.I.U.R.: “Stereoselezione in Sintesi Organica: Metodologie ed Applicazioni”, Camerino, 27-28 febbraio 2003. Presentazione orale: “Sintesi di nuovi eterocicli spiro precursori di -epossi--amminoacidi”.

• Giornata di studio “NMR in Puglia: ambiente, salute” tenuta a Bari, 1 giugno 2001, organizzata dal consorzio C.I.R.C.M.S.B.

• “IX Joint Meeting on Heterocyclic Chemistry”, Urbino, 5-9 maggio 2004. Presentazione poster: -Lithiated Oxazolinyloxiranes for the Stereoselective Synthesis of 4,5-Epoxy-1,2-oxazin-6-ones”.

• “5th Spanish-Italian Symposium on Organic Chemistry (SISOC-5)”, Santiago de Compostela , 10-13 settembre 2004. Presentazione poster: “Stereoselective Synthesis of 4,5-Epoxy-1,2-oxazin-6-ones via Reaction of -Lithiated Oxazolinyloxiranes and Nitrones”.

• “Ischia Advanced School of Organic Chemistry”, Ischia, 18-23 settembre 2004. Presentazione poster: “-Aryl-Substituted Oxazolinyloxiranyllithiums-Mediated Stereoselective Synthesis of 4,5-Epoxy-1,2-oxazin-6-ones”.

• “Riunione Scientifica della Sezione Puglia- 2004 – La chimica per la qualità della vita”, Bari, 16-17 dicembre 2004. Presentazione orale: “Stereoselective Synthesis of 4,5-Epoxy-1,2-Oxazin-6-ones via Reaction of -Lithiated Oxazolinyloxiranes with Nitrones”.

• “First Austrian-German-Italian Meeting of Organic Chemistry”, Vienna, 1-2 aprile 2005. Presentazione poster: “On the Addition of Lithiated Alkyloxazolines with Nitrones”.

• XXII Eupopean Colloqium on Heterocyclic Chemistry, Bari, 2-6 Settembre 2006. Presentazione poster: “On the Addition of Lithiated Alkyloxazolines to Nitrones”.

• XXXII Convegno Nazionale della Divisione di Chimica Organica, Taormina, 26-30 Luglio 2008. Presentazione Orale: “Sintesi Stereoselettiva di Nuovi Derivati 2,2,3-Amminoacidici non Naturali.
 

Publications:

1)  Saverio Florio, Vito Capriati, Renzo Luisi, Leonardo Degennaro

     “A highly stereoselective synthesis of a,b-unsaturated oxazolines” 

    Tetrahedron Lett. 2001, 42, 9183-9186.


2)   Saverio Florio, Vito Capriati, Renzo Luisi, Alessandro Abbotto, Leonardo Degennaro and Antonio Salomone
      “A stereospecific: Synthesis of Oxazolinyloxiranes” 

     J. Org. Chem. 2001, 66, 3049-3058.


3)  Saverio Florio, Vito Capriati, Renzo Luisi, Leonardo Degennaro, Carmela Tralli, Luigino Troisi 

     “Lithiation of 2-(1-Chloroethyl)-2-oxazolines: “Synthesis of substituted oxazolinyloxiranes and oxazolinylaziridines”. 

    Synthesis. 2001, 15, 2299-2306.

 

4) Vito Capriati, Leonardo Degennaro, Saverio Florio, and Renzo Luisi

     “On the Addition of Lithiated 2-Alkyl- and 2-(Chloroalkyl)-4,5-dihydro-1,3-oxazoles to Nitrones – A Mechanistic Investigation”

     Eur. J. Org. Chem. 2002, 2961-2969.

 

5)  Vito Capriati, Leonardo Degennaro, Raffaele Favia, Saverio Florio and Renzo Luisi

     "Stereospecific b-lithiation of oxazolinyloxiranes: Synthesis of a,b-epoxy-g-butyrolactones"

     Org. Lett. 2002, 1551-1554.

 

6 Renzo Luisi, Vito Capriati, Leonardo Degennaro, Saverio Florio

      “Oxazolinyloxiranyllithium-Mediated Stereoselective Synthesis of a-Epoxy-b-Amino Acids”

     Org. Lett. 2003, 5 (15) 2723–2726.

          

7)  Renzo Luisi, Vito Capriati, Claudia Carlucci, Leonardo Degennaro, Saverio Florio

      “Lithiation of Optically Active Oxazolinyloxiranes: Configurational Stability”

      Tetrahedron 2003, 59, 9707–9712.

          

8)  Renzo Luisi, Vito Capriati, Leonardo Degennaro, Saverio Florio

      “Oxazolinyloxiranyllithium-Mediated Synthesis of Highly Strained Hetrocyclic Compounds”

      Tetrahedron 2003, 59, 9713–9718 .

 

9) Saverio Florio, Vito Capriati, Leonardo Degennaro, Renzo Luisi, Filippo Maria Perna

     "Novel oxazoline-mediated Syntheses of heterocycles" Oxygen-and Sulfur-Containing Heterocycles, The Chemistry and Biological Activity of Synthetic   and Natural Compounds, IBS Press, 2003, Vol 1, 66.

 

10) Vito Capriati , Leonardo Degennaro, Saverio Florio, Renzo Luisi, Pasqualina Punzi

“Stereoselective Synthesis of Novel 4,5-Epoxy-1,2-oxazin-6-ones and a,b-Epoxy-g-amino Acids from b-Lithiated Oxazolinyloxiranes and Nitrones”  Org. Lett. 2006, 8, 4803-4806.

 

11) Vito Capriati , Leonardo Degennaro, Saverio Florio and Renzo Luisi

"Oxazoline-mediated highly stereoselective synthesis of a,b-substituted-b-aminoalkanamides, potential precursors of unnatural b2,2,3-amino acids"

Tetrahedron Letters  2007,48, 8651-8658.

 

12) Vito Capriati , Leonardo Degennaro, Saverio Florio, Renzo Luisi and Corrado Cuocci

"Asymmetric synthesis of a,b-substituted b-aminoalkanamides and stereochemical determination"

Tetrahedron Letters 2007,48, 8655-8658.

 

13) Capriati V., Degennaro L., Forio S., Luisi R.,  Moliterni A. and  Rizzi R.. “Crystal structure of (2R*,3R*)-3-amino-2-ethyl-N-(2-hydroxy-1,1-dimethylethyl)-3-p-methoxyphenylpropanamide, C17H28N2O3”. Zeitschift Fur Kristallographie, 2008, vol. 223; p. 483-484, ISSN: 0044-2968

 

14) Capriati V., Degennaro L., Forio S., Luisi R., Cuocci C. and  Campi G. . “Crystal Structure of (+)-(2S,3S,1’S)-2-Ethyl-N-(1-Hydroxymethyl-2-Methylpropyl)-2-Methyl-3-Phenyl-3-Phenylamino Propanamide, C23H32N2O2”. Zeitschift Fur Kristallographie, 2008, vol. 223; p. 481-482, ISSN: 0044-2968

 

15) Degennaro L., Capriati V.,  Carlucci C.,  Florio S.,  Luisi R., Nuzzo I., Cuocci C.. Terminal Oxazolinyloxiranes: Synthesis, Reaction with Amines and Regioselective β-Lithiation. Tetrahedron, 2009, vol. 65; p. 8745-8755, ISSN: 0040-4020, doi: 10.1016/j.tet.2009.08.040

 

16) Dammacco M., Degennaro L., Florio S., Luisi R., Musio B. and Altomare A.. Lithiation of N-Alkyl-(o-tolyl)aziridine: Stereoselective Synthesis of Isochromans. Journal of Organic Chemistry, 2009, vol. 74; p. 6319-6322, ISSN: 0022-3263, doi: 10.1021/jo9011943