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RESEARCH

 

 

STUDENTS

 

Ph. D RECIPIENTS

                    UNIVERSITA' DEGLI STUDI DI BARI

 

  

Saverio Florio
Dipartimento Farmaco Chimico
Università di Bari
Via E. Orabona, 4
I-70125 Bari (Italy).
Tel: +39.080.5442749/2251
Fax: +39.080.5442539
E-mail: florio@farmchim.uniba.it

 

Saverio Florio studied and received his "Laurea in Chemistry" at the University of Bari (Italy) in 1967 under Professor Paolo E. Todesco's supervision. He started his academic career at the same University of Bari as Assistant Professor in 1969. He became Associate Professor of Organic Chemistry at the University of Bari in 1982. Four years later, in 1986, he was appointed Full Professor of Organic Chemistry at the University of Lecce and in 1990 moved to the University of Bari, where he has been ever since, as Full Professor of Organic Chemistry of the Faculty of Pharmacy.

 

PROFESSIONAL ACTIVITY

- Head of the Department of Medicinal Chemistry (Dipartimento Farmaco-Chimico) from 1994 to 1997.

- Member of the Advisory Board of the of the Division of Organic Chemistry of the Italian Chemical Society 1993-1995

- Vice-President of the Division of Organic Chemistry of the Italian Chemical Society 1996-1997

- President of the  of the Division of Organic Chemistry of the Italian Chemical Society from 1997 to 2001 and  Past-President from 2001 to 2004.

- Director of the Interuniversities Consorzium "Metodologie e Processi Innovativi di Sintesi" since its istitution (1994).

- Member of the Scientific Advisory Board of the “Ischia Advanced School of Organic Chemistry” (IASOC School).

- Member of the Board of Consulting Editors of Tetrahedron and Tetrahedron Letters.

- Member of the Academic Senate of the University of Bari from 2009.

- Vice President of the Italian Chemical Society (2008-2010).

RESEARCH COLLABORATIONS

- Research Fellow, University College of Bangor, North Wales, UK. Research Activity with Prof. Charles Stirling and ICI of Manchester, October  1978 to September 1979.

- Collaboration with several italian and european Universities.

- NATO Travel Awards with Prof. Theodore Cohen of the University of Pittsburgh, 1993 and 1997.

- Research Collaboration with Dompè Spa, L’Aquila, Italy.

- Research Collaboration with Angelini Spa, Frosinone, Italy.  

 

AWARDS

 

- Ziegler-Natta Lecture  for 2005  by  the German Chemical Society 

- Member of the European Accademy of Arts and Sciences Salsburg 2007

- Gold Medal "Angelo Mangini" of the Division of Organic Chemistry of the Italian Chemical Society for 2007

- First Lecturer of the Slovenian-Italian Lectureship 2010

 

PROFESSIONAL SOCIETIES

- Società Chimica Italiana since 1968

- American Chemical Society since 1990

- Royal Chemical Society since 1983  

- International Society of Heterocyclic Chemistry since 2002

 

 

SCIENTIFIC ACTIVITY

Prof. Florio's research interests concern:

- synthesis and reactivity of heterocyclic compounds;

- organometallic reagents;

- stereochemistry of aldol reactions;

- chemistry and synthetic applications of a-heterosubstituted carbanions;

- asymmetric synthesis.

 

RECENT LECTURES

-Chiral Heterosubstituted Azaenolates: Useful Intermediates in Asymmetric Synthesis, The Eighth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-8), Kyoto (Japan), July 11-15, 2000.

-Heterosubstituted Azaenolates in Asymmetric Synthesis, Second French Italian Symposium on Organic Chemistry Stereocontrol and New Targets, Strasbourg, November 24-25, 2000.  

-New Acquisition in Oxazoline Chemistry, 2nd Italian-Japanese Symposium of Organic Chemistry (JISOC-2), Kyoto, (Japan), November 28-30, 2001.

-Oxiranyl and Aziridinyl Anions: Applications in Synthesis, XXVI Summer School "A. Corbella", Seminars in Organic Synthesis, Palazzo Feltrinelli, Gargnano (BS), June 18-22, 2001.

-Oxiranylanions Mediates Synthesis of Heterocycles, 8th IBN SINA, International Conference on Pure and Applied Heterocyclic Chemistry, Luxor (Egypt), February 16-19, 2002.  

-Lithiation of Oxazolinyloxiranes: Synthetic Application, 8th RSC-SCI, Joint Meeting on Heterocyclic Chemistry, Edinburg (Scotland), May 16-19, 2002.

-Asymmetric Organic Synthesis: Principles and Methods

XXIII Corso Avanzato in Chimica Farmaceutica e Seminario Nazionale per Dottorandi “E. Duranti” Urbino, Italy, July 1-5 2002.

 

- Novel Oxazoline-Mediated Synthesis of Heterocycles

19th International Congress of Heterocyclic Chemistry, Fort Collins, Colorado (USA), August 10-15 2003.  

 

-Novel Oxazoline-Mediated Synthesis of Heterocycles: Chemistry and Biological Activity of Oxygen- and Sulfur-containing Heterocycles; Moscow, Russia, October 14-17, 2003

 

- Stereoselective Oxazoline-Mediated Synthesis of Amino Acids and Epoxylactones

33rd Krka Prizes – 13th International Symposium, Novo Mesto, Slovenia, October 23-24 2003.

 

- Stabilized Oxiranyl Anions: Synthetic Utility

IX Joint Meeting on Heterocyclic Chemistry, Urbino, 5-9 May 2004.

 

- Oxiranyllithiums: Useful Reactive Intermediates

7th International Symposium on Carbanion Chemistry (ISCC-7), Alicante, Spain, July 7-11, 2004.

 

- Oxiranyllithiums-Mediated Synthesis of Strained Heterocyclic Compounds

5th Spanish Italian Symposium on Organic Chemistry (SISOC-5), Santiago de Compostela, Spain, September 10-13, 2004.

 

- Oxazolinyloxiranyllithiums: Useful Reactive Intermediates in Synthetic Organic Chemistry

XXI European Colloquium on Heterocyclic Chemistry, Sopron, Hungary, September 12-15, 2004.

 

- Novel Oxazoline-Mediated Synthesis of Heterocycles

Transmediterranean Colloquium on Heterocyclic Chemistry, Tramech 2004,

Marrakesh, November 23-27, 2004.

 

- Recent Developments in the Chemistry of Lithiated Epoxides

First Austrian-German-Italian, Meeting of Organic Chemistry

Vienna, Austria, April 1-2, 2005.

 

- Syntheses Using the Oxiranyl Anion Methodology

Ischia Advanced School of Organic Chemistry” (IASOC School)

Ischia (NA), September 16-21, 2006.

 

- Ortho-Lithiation of Aziridines and Oxiranes: a Useful Synthetic Methodology

10th IBN SINA International Conference on Pure and Applied Heterocyclic Chemistry

Luxor, Egypt, February 17-20, 2007.

 

- Regio and Stereoselective Lithiation of Arylaziridines

18th Lakeland Symposium on Heterocyclic Chemistry

Grasmere, UK, May 10-14, 2007.

 

- Effets du Solvant et des Substituants sur la Métallation Régio et Stéréosélective des Aziridines

Journées de Chimie Organique

Palaiseau (France) 17-19 Septembre 2007.

 

- Litiando Ossirani: una Innovativa Metodologia di Sintesi

VII Laboratorio di Metodologie Sintetiche in Chimica Farmaceutica

Siena, 17-22 febbraio 2008.

 

- Lithiated Aziridines: Useful Vehicles for Organic Synthesis

11th IBN SINA INternationale Conference on Pure and Applied Heterocyclic Chemistry

Cairo, 13-16 December 2008.

 

- Regio- and Stereoselective Lithiation of Aziridines: Solvent, Temperature and Ring Substitution Effects

12th European Symposium on Organic Reactivity

Haifa, Israel, 6-11 September 2009.

 

- Mechanistic, Stereochemical and Synthetic Aspects of the Lithiation Reaction of Aziridines

Transmediterranean Colloquium on Heterocyclic Chemistry (TRAMECH-6)

Yasmine Hammamet, Tunisia, 5-7 november 2009.

TEACHING ACTIVITY

1990-Present              

(University of Bari):       "Organic Chemistry II Part" for Chemistry and Pharmaceutical Technologies 

                                        "Organic Chemistry" for Pharmacy.

1984/1987/1992/2002 :  Lecturer at the"Summer School of Organic Chemistry" of Gargnano (University of 

                                        Milano) organized by the "Division of Organic Chemisty of the Italian Chemical Society".

 

RECENT PUBLICATIONS

 

 

-  S. Florio, V. Capriati, R. Luisi

  “Highly Stereoselective Synthesis of Optically Active Oxazolinyl Oxiranes from Azaenolates of a Chiral 2-Chloromethyloxazoline”,

   Tetrahedron Lett. 2000, 41, 5295–5298.

 

-  V. Capriati, S. Florio, R. Luisi, V. Russo and A. Salomone

  “Oxiranyllithium Based Synthesis of a-Keto-2-Oxazolines”,

  Tetrahedron Lett. 2000, 41, 8835–8838.

  

-  S. Florio, L. Troisi, V. Capriati and G. Suppa

   “Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines”,

   Eur. J. Org. Chem. 2000, 3793–3797.

 

-  S. Florio, V. Capriati, R. Luisi

   “Azaenolates of 2-Chloromethyl-4-methoxymethyl-5-phenyl-2-oxazoline: Highly Diastereo-  and Enantioselective Synthesis of   Oxazolinyloxiranes”,

   Eur. J. Org. Chem. 2001, 2035–2039.

 

-  A. Abbotto, V. Capriati, L. Degennaro, S. Florio, R. Luisi, M. Pierrot and A. Salomone

   “A Stereospecific Synthesis of Oxazolinyloxiranes”,

  J. Org. Chem. 2001, 66, 3049–3058.

 

-  A. Abbotto, V. Capriati, S. Florio, R. Luisi, D. J. Pippel

   “On the Coupling Reaction of Lithium Azaenolates of Chiral Oxazolines with Carbonyl Compounds”,

  Tetrahedron 2001, 57, 6775-6786.

 

-  Vito Capriati, Leonardo Degennaro, Saverio Florio, Renzo Luisi

   “A Highly Stereoselective Synthesis of a,b-Unsaturated Oxazolines”

  Tetrahedron Lett. 2001, 42, 9183-9186.

 

-  Vito Capriati, Leonardo Degennaro, Saverio Florio, Renzo Luisi, Carmela Tralli, Luigino Troisi

    “Lithiation of    2-(1-Chloroethyl)-2-oxazolines: Synthesis of Substituted Oxazolinyloxiranes and Oxazolinylaziridines”

    Synthesis 2001, 15, 2299-2306.

 

-  Vito Capriati, Saverio Florio, Giovanni Ingrosso, Carla Granito, Luigino Troisi

    “[1,2] and [2,3]-Wittig Stereoselective and Competitive Rearrangements of Heteroarylalkyl Allyl Ethers”

    Eur. J. Org. Chem. 2002, 478-484.

 

-  Vito Capriati, Saverio Florio, Renzo Luisi, Maria Teresa Rocchetti

    “Metallation of 2-chloromethyl-2-oxazoline: synthesis of 1,2,3-Tris(oxazolinyl)cyclopropanes and Derivatives”

    J. Org. Chem. 2002, 67, 759-763.

 

- Vito Capriati, Leonardo Degennaro, Raffaele Favia, Saverio Florio and Renzo Luisi

    “Stereospecific b-lithiation of oxazolinyloxiranes: Synthesis of a,b-epoxy-g-butyrolactones”   

    Org. Lett. 2002, 1551-1554.

 

- Vito Capriati, Saverio Florio, Renzo Luisi and Antonio Salomone

   “Oxiranyl Anion-Mediated Synthesis of Highly Enantiomerically Enriched Styrene Oxide Derivatives”

    Org. Lett. 2002, 4 (14), 2445-2448.

          

-  Vito Capriati, Leonardo Degennaro, Saverio Florio, and Renzo Luisi

    “On the Addition of Lithiated 2-Alkyl- and 2-(Chloroalkyl)-4,5-dihydro-1,3-oxazoles to Nitrones – A Mechanistic Investigation”

   Eur. J. Org. Chem. 2002, 2961-2969.

          

-  Filippo Maria Perna,Vito Capriati, Saverio Florio and Renzo Luisi

   “An unexpected base-promoted isomerization of oxazolinylaryl oxiranes: synthesis of oxazolinyl alkanones”

   Tetrahedron Lett. 2002, 43, 7739-7742.

          

-  Filippo Maria Perna,Vito Capriati, Saverio Florio and Renzo Luisi

   “Synthesis of Allylic Alcohols from Oxazolinyloxiranes”

   J. Org. Chem. 2002, 67, 8351-8359.

          

-  Saverio Florio, Catia Granito, Giovanni Ingrosso, Luigino Troisi

   “Wittig Rearrangements of (Heteroaryl)alkyl Propargyl Ethers – Synthesis of Allenic and Propargylic Alcohols”

   Eur. J. Org. Chem. 2002, 20, 3465-3472.

          

-  Saverio Florio, Catia Granito, Giovanni Ingrosso, Luigino Troisi

   “Regio- and Stereo-selective Coupling Reactions of Heteroarylalkyl Propargyl Ethers with Electrophiles”

   ARKIVOC 2002(xi) 216–226.

          

-  Maria Teresa Rocchetti, Vincenzo Fino, Vito Capriati, Saverio Florio and Renzo Luisi

   “Michael Addition of Chloroalkyloxazolines to Electron-Poor Alkenes: Synthesis of Heterosubstituted Cyclopropanes ”

   J. Org. Chem. 2003, 68, 1394–1400.

          

-  Ludovico Ronzini, Saverio Florio, Fabio Bona, Luisella De Vitis, and Luigino Troisi

   “Diasteroselective Synthesis of 2-Oxiranyl and 2-Aziridinyl Thiazoles”

   Tetrahedron 2003, 59, 1381–1387.

          

-  Renzo Luisi,Vito Capriati, Saverio Florio, Rosa Ranaldo

   “On the Lithiation of Oxazolinylaziridines”

   Tetrahedron Lett. 2003, 44, 2677–2681.

          

-  Filippo Maria Perna, Vito Capriati, Saverio Florio, Renzo Luisi

   “Isomerization of Oxazolinyl Allylic Alcohols: Synthesis of 3-Alkylidene-2-Iminooxetanes”

  Tetrahedron Lett. 2003, 44, 3477–3481.

          

-  Renzo Luisi, Vito Capriati, Leonardo Degennaro, Saverio Florio

   “Oxazolinyloxiranyllithium-Mediated Stereoselective Synthesis of a-Epoxy-b-Amino Acids”

   Org. Lett. 2003, 5 (15) 2723–2726.

          

-  Renzo Luisi, Vito Capriati, Claudia Carlucci, Leonardo Degennaro, Saverio Florio

   “Lithiation of Optically Active Oxazolinyloxiranes: Configurational Stability”

    Tetrahedron 2003, 59, 9707–9712.

          

-  Renzo Luisi, Vito Capriati, Leonardo Degennaro, Saverio Florio

   “Oxazolinyloxiranyllithium-Mediated Synthesis of Highly Strained Hetrocyclic Compounds”

   Tetrahedron 2003, 59, 9713–9718..

          

- Saverio Florio, Patrizia Lorusso, Catia Granito, Ludovico Ronzini, Luigino Troisi

  “Vicarious Nucleophilic Substitution of Chloroalkyloxazolines with Nitroarenes: Synthesis of Nitrobenzyloxazolines”

   Eur. J. Org. Chem. 2003, 4053–4058.

          

- Vito Capriati, Raffaele Favia, Saverio Florio, Renzo Luisi

   “b-Lithiation of Oxazolinyloxiranes: Synthetic Utility”

   ARKIVOC 2003, xiv, 77–86.

          

- Renzo Luisi,Vito Capriati, Saverio Florio, Teresa Vista

  “A New Synthesis of Optically Active 5-Isoxazolidinones and b-Amino Acids”

  J. Org. Chem. 2003, 68, 9861–9864.

          

- Renzo Luisi, Vito Capriati, Saverio Florio, Eliana Piccolo

  “Synthesis of Enantiomerically Enriched Oxazolinyl[1,2]Oxazetidines”

  J. Org. Chem. 2003, 68, 10187-10190.

 

-   Saverio Florio, Vito Capriati, Leonardo Degennaro, Renzo Luisi, Filippo Maria Perna

     "Novel oxazoline-mediated Syntheses of heterocycles" Oxygen-and Sulfur-Containing Heterocycles, The Chemistry and Biological Activity of Synthetic and Natural Compounds

     IBS Press, 2003, Vol 1, 66.

 

- Luisella De Vitis, Saverio Florio, Catia Granito, Ludovico Ronzini, Luigino Troisi, Vito Capriati, Renzo Luisi, Tullio Pilati

  “Stereoselective Synthesis of Heterosubstituted Aziridines and their Functionalization”

  Tetrahedron 2004, 60, 1175-1182.

          

- Saverio Florio, Patrizia Lorusso, Renzo Luisi, Catia Granito, Ludovico Ronzini, Luigino Troisi

  “Vicarious Nucleophilic Substitution of Chloroalkylheterocycles with Nitroarenes”

  Eur. J. Org. Chem. 2004, 2118-2124.

          

-  Saverio Florio, Patrizia Lorusso, Catia Granito, Renzo Luisi, Luigino Troisi

  “One-pot regioselective synthesis of nitrophenyloxazolinyl styrene oxides by the darzens reaction of vicarious nucleophilic

   substitution-formed carbanions of 2-dichloromethyl-4,4-dimethyloxazoline”

   J. Org. Chem. 2004, 69, 4961-4965.

 

-   Vito Capriati, Saverio Florio, Renzo Luisi, Irene Nuzzo

     “Stereospecific Synthesis of Optically Active Phenylpropylene Oxides”

     J. Org. Chem. 2004, 69, 3330-3335.

 

-   Saverio Florio, Filippo Maria Perna, Renzo Luisi, José Barluenga, Francisco J. Fananas, Felix Rodriguez

    "A Synthetic Approach to Substituted Cyclopropanes Based on the Coupling Reaction of Lithiated Chloroalkyloxazoline with

     Fischer Carbene Complexes"

     J. Org. Chem. 2004, 69, 5480-5482.

 

-   Saverio Florio, Vito Capriati, Renzo Luisi

    “Lithiated a-Chloroalkylheterocycles: Utility in Synthetic Organic Chemistry”

     Curr. Org. Chem. 2004, 8,1529-1545.

 

   Saverio Florio, Filippo M. Perna, Vito Capriati, Renzo Luisi, Claudia F. Martina, José Barluenga, Francisco J. Fañanas, Félix

       Rodríguez

      “Synthesis of a-Oxazolinylalkanamides”

       Tetrahedron Lett. 2004, 45, 8027-8030.

 

-     Saverio Florio, Varinder Aggarwal, Antonio Salomone

      Lithiation and Reactions of Stilbene Oxides: Synthetic Utility

      Organic Letters, 2004, 6, 4191-4194.

 

-    Florio, S.; Perna, F.M.; Luisi, R.; Barluenga, J.; Fañanas, F:J.; Rodríguez, F.

     "Stereoselective Synthesis of Pentacarbonyl (3-Oxa-2-Bicyclo[3.1.0]Hexylidene)-and Pentacarbonyl (Cyclopropyl

     Methoxymethylene)-Tungsten compounds on the Route to Cyclopropane-γ-Lactones and -Carboxylates"

     J. Org. Chem, 2004, 69, 9204-9207.

 

-    Renzo Luisi, Vito Capriati, Saverio Florio

     “Asymmetric Synthesis of Highly Strained Heterocyclic Compounds and of b- and g-Amino Acids Using a Very Innovative  Methodology”

     Anales de la Real Sociedad Española de Quimica, 2004,100 (4),19-26.

 

-    Vito Capriati, Saverio Florio, Renzo Luisi 

      a-Lithiated Aryloxiranes: Useful Reactive Intermediates

     Synlett  2005, 9, 1359-1369.

 

-    Renzo Luisi, Vito Capriati, Saverio Florio, Peppino Di Cunto, Biagia Musio

     Synthesis and Lithiation of oxaxolinylaxiridines: the N-substituent effect.

     Tetrahedron 2005, 61, 3251-3260. 

 

-   Marcello Allegretti, Riccardo Bertini, Maria Candida Cesta, Cinzia Bizzarri, Rosa Di Bitonto, Vito Di Cioccio, Emanuela Galliera, 

    Valerio Berdini, Alessandra Topai, Giuseppe Zampella, Vincenzo Russo, Nicoletta Di Bello, Giuseppe Nano, Luca Nicolini,

    Massimo Locati, Piercarlo Fantucci, Saverio Florio and Francesco Colotta

    2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors

    J. Med. Chem. 2005, 48, 4312-4331.

 

-   Saverio Florio, Vito Capriati, Renzo Luisi, Filippo Maria Perna, José Barluenga

    Asymmetric Synthesis of Cyclopropane from Lithiated Aryloxiranes and a,b-Unsaturated Fischer Carbene Complexes

    J. Org. Chem. 2005, 70, 5852-5858.

 

-  Renzo Luisi, Vito Capriati, Saverio Florio, Biagia Musio

   Direct Ortho Lithiation of N-Alkylphenylaziridines

   Org. Lett. 2005, 7, 3749-3752.

 

-  Vito Capriati, Saverio Florio, Renzo Luisi, Filippo Maria Perna, Antonio Salomone, and Francesco Gasparrini

   An Efficient Route to Tetrahydronaphthols via Addition of Ortho-Lithiated Stilbene Oxides to a,b-Unsatured Fischer Carbene Complexes.

    Org. Lett. 2005, 7, 4895-4898.

 

- Vito Capriati, Saverio Florio, Renzo Luisi, Filippo M. Perna, and Antonio Salomone

     Synthesis of 1,3-Dihydrobenzo [c] furans from Ortho-Lithiated Aryloxiranes

     J. Org. Chem. 2006, 70, 3984-3987.

 

 - Vito Capriati , Saverio Florio, Renzo Luisi, Antonio Salomone, Corrado Cuocci

      "Stereoselective Synthesis of Novel b,g-Epoxyhydroxylamines and 4-Hydroxyalkyl-1,2-Oxazetidines”

     Org. Lett. 2006, 8 (18), 3923–3926.

 

- Vito Capriati , Leonardo Degennaro, Saverio Florio, Renzo Luisi, Pasqualina Punzi

“Stereoselective Synthesis of Novel 4,5-Epoxy-1,2-oxazin-6-ones and a,b-Epoxy-g-amino Acids from b-Lithiated Oxazolinyloxiranes and Nitrones”

   Org. Lett. 2006, 8, 4803-4806.

 

Saverio Florio, Vito Capriati, Renzo Luisi, Antonio Salomone and Corrado Cuocci  

   Crystal structure of (N-tert-butyl-3,4-diphenyl-1,2-oxazetidin-4-yl) methanol, C19H23NO2

   Z. Kristallogr. NCS 2006, 221, 1-3.

 

- Luigino Troisi, Catia Granito, Claudia Carlucci, Fabio Bona, and Saverio Florio

  Synthesis and Functionalisation of 2,3-Diheterocycle-Substituted Aziridines

  Eur. J. Org. Chem. 2006, 775-781.

 

- Saverio Florio, Mieczyslam Makosza, Patrizia Lorusso, and Luigino Troisi

  Oxidative nucleophilic substitution of hydrogen in nitroarenes with an oxazoline-stabilized carbanion

   ARKIVOC 2006, (vi) 59–66.

 

- Luisi Renzo, Capriati Vito, Florio Saverio, and Musio Biagia

  Regio - and Stereoselective Lithiation and Electrophilic Substitution Reactions of N-Alkyl-2,3-diphenylaziridines: Solvent Effect

  Org. Lett. 2007, 1263-1266.

 

- Vito Capriati, Saverio Florio, Renzo Luisi, Filippo M. Perna

  Synthesis of Substituted 2,3-Dihydro-10bH-oxazolo[2,3-a]isoquinolines from ortho-Lithiated Phenyloxazolinyloxiranes

  J. Org. Chem. 2007, 72, 6316-6319.

 

- Renzo Luisi, Vito Capriati, Peppino Di Cunto, Saverio Florio, and Rosmara Mansueto

Regio- and Stereoselective Lithiation of Terminal Oxazolinylaziridines: The Aziridine N-Substituent and the Oxazolinyl Group Effect

Organic Letters 2007, 9, 3295-3298.

 

- Vito Capriati , Leonardo Degennaro, Saverio Florio and Renzo Luisi

"Oxazoline-mediated highly stereoselective synthesis of a,b-substituted-b-aminoalkanamides, potential precursors of unnatural b2,2,3-amino acids"

Tetrahedron Letters 2007,48, 8651-8658.

 

- Vito Capriati , Leonardo Degennaro, Saverio Florio, Renzo Luisi and Corrado Cuocci

"Asymmetric synthesis of a,b-substituted b-aminoalkanamides and stereochemical determination"

Tetrahedron Letters 2007,48, 8655-8658.

 

- Caterina Maugeri, Maria A. Alisi, Claudia Apicella, Luciano Cellai, Patrizia Dragone, Elena Fioravanzo, Saverio Florio, Guido Furlotti, Giorgina Mangano, Rosella Ombrato, Renzo Luisi, Raffaello Pompei, Vito Rincicotti, Vincenzo Russo, Marco Vitiello and Nicola Cazzolla

"New anti-viral drugs for the treatment of the common cold"

Bioorganic & Medical Chemistry 2008,16, 3091-3107.

 

- Vito Capriati, Saverio Florio, Renzo Luisi, Andrea Mazzanti, and Biagia Musio

"Regio- and Stereoselective Lithiation of 2,3-Diphenylaziridines: A Multinuclear NMR Investigation"

J. Org. Chem. 2008, 73,(8), 3197-3204.

 

- Antonio Salomone, Vito Capriati, Saverio Florio, and Renzo Luisi

"Michael Addition of Ortho-Lithiated Aryloxiranes to alpha,beta-Unsaturated Malonates: Synthesis of Tetrahydroindenofuranones"

Organic Letters, 2008, 10, 1947-1950.

 

- Vito Capriati, Saverio Florio, Renzo Luisi

"a-Substituted a-Lithiated Oxiranes: Useful Reactive Intermediates" 

Chemical Review. 2008, 108, 1918-1942.

 

- Saverio Florio, Vito Capriati, Renzo Luisi

Comprehensive Heterocyclic Chemistry III; Katritzky, A.R., Pergamon: Oxford, 2008; Chapter 2.14: Four-Membered Rings with One Oxygen and One Nitrogen Atom 2008, 689-711.

 

- Florio S., Capriati V., Luisi R.

"Four-membered Rings with One Oxygen and One Nitrogen Atom" in Comprehensive Heterocyclic Chemistry III.

Gainesville: Katritzky, A.R., 2008, vol.3, 690.

 

- Affortunato F.  Florio S.,   Luisi R., Musio B.

   a-vs Ortho-Lithiation  of N-Alkylarylaziridines: Probing the Role of the Nitrogen Inversion Process.

   Journal  of Organic Chemistry. 2008, 73,  9214-9220.

 

- Capriati, V, Florio S., Luisi R, Musio B, Alkorta I, Blanco F., Elguero J.

A computational study of the effect of C-lithiation on the NMR properties (chemical shifts and coupling constants) of aziridines.

 Journal  of Structural Chemistry. 2008, 785-792.

 

- Capriati, V, Florio S., Luisi R, Perna, F. M, Spina, A.

 2-Lithio-3,3-dimethyl-2-oxazolinyloxirane: Carbanion or Azaenolate? Structure, Configurational Stability, and Stereodynamics in Solution.

 Journal of  Organic Chemistry. 2008, 73 , 9552-9564.

 

- Musio B., Clarkson G. J., Shipman M., Florio S., and Luisi R.

Synthesis of Optically Active Arylaziridines by Regio-and Stereospecific Lithiation of N-Bus-Phenylaziridine

Organic Letters. 2009, 11, 325-328.

 

- Vito Capriati, Florio S., Luisi R, Antonio Salomone, Maria Giovanna Tocco, Ana M. Martín Castro, José Luis García Ruano, Esther Torrente.

Influence of an ortho-sulfinyl group on the configurational stability of α-lithiated aryloxiranes: deuteration of tolylsulfinyl styrene oxides.

Tetrahedron. 2009, 65, 383-388.

 

- Capriati V., Florio S., Perna F.M., Salomone A., Abbotto A., Amedjkouh M., Nilson Lill So

On the dichotomic reactivity of lithiated styrene oxide: a computational and multinuclear magnetic resonance investigation

Chemistry-A European Journal, 2009, 15, 7958-7979.

 

- Dammacco M., Degennaro L., Florio S., Luisi R., Musio B., Altomare A.

Lithiation of N-Alkyl-(-tolyl)aziridine: Stereaselective Synthesis of Isochromans-o

Journal of Organic Chemistry, 2009,74, 6319-6322.

 

- Leonardo Degennaro, Vito Capriati, Claudia Carlucci, Saverio Florio, Renzo Luisi, Irene Nuzzo, Corrado Cuocci
Terminal oxazolinyloxiranes: synthesis, reaction with amines and regioselective β-lithiation
Tetrahedron, 2009, 65, 8745-8755

 

- Florio S., Capriati V., Salomone A.

Oxiranyllithiums as Chiral Synthons for Asymmetric

In Topics in Stereochemistry, Ed. Siegel J. S.  2010, Vol 26, 135.

 

- Florio, S.; Luisi R.

Aziridinyl Anions: Generation, Reactivity, and Use in Modern Synthetic Chemistry

Chem. Rev. 2010, 5128

 

- Capriati V, Florio S, Perna FM, Salomone, A.

Lithiated Fluorinated Styrene Oxides: Configurational Stability, Synthetic Applications, and Mechanistic Insight

Chemistry-A European Journal  2010, 32, 9778-9788

 

- Capriati V, Florio S

Anatomy of Long-Lasting Love Affairs with Lithium Carbenoids: Past and Present Status and Future Prospects

Chemistry-A European Journal   2010, 16, 4152-4162

 

- Luisi R, Giovine A, Florio S

New Arylaziridinyldifluoroborates: Useful Suzuki-Miyaura Reagents

Chemistry-A European Journal  2010, 16, 2683-2687

 

- Ruano JLG, Martin-Castro AM, Tato F, Esther TorrenteMaria Giovanna ToccoSaverio FlorioVito Capriati

Stereoselective synthesis of 2,3-epoxy alcohols mediated by a remote sulfinyl group

Tetrahedron  2010, 66, 1581-1585

 

- Affortunato, F.; Degennaro, L.; Florio, S.; Giovine, A.; Luisi, R.; Mansueto, R.; Musio, B.

New Horizons in the Chemistrof Aziridines

Chemistry and Biological Activity of Synthetic and Natural Compounds: Modern Aspects of Chemistry of Heterocycles (CBC-2010)

ICSPF, 2010, pg 38-49.

 

- Perna, F. M.; Salomone, A.; Dammacco, M.; Florio, S.; Capriati, V.

Solvent and TMEDA Effects on the Configurational Stability of Chiral Lithiated Aryloxiranes.

Chemistry-A European Journal  2011, 17, 8216-8225

 

- Capriati, V.; Dammacco, M.; Florio, S.;. Perna, F. M.; Salomone, A.

On the Configurational Stability of alpha-Lithiated Sulfurated Styrene Oxides: Synthetic and Mechanistic Aspects

Proceedings of ISOCS-24, 2011, 186, 1274-1277

 

- Degennaro, L.; Mansueto, R.; Carenza, E.; Rizzi, R.; Florio, S.; Pratt, L. M.; Luisi, R.

Nitrogen Dynamics and Reactivity of Chiral Aziridines: Generation of Configurationally StableAziridinyllithiums.

Chemistry-A European Journal  2011, 17, 4992-5003

               

- De Ceglie, M. C.; Musio, B.; Affortunato, F.; Moliterno, A.; Altomare, A.; Florio, S.; Luisi, R.

Solvent- and Temperature-Dependent Functionalisation of Enantioenriched Aziridines

Chemistry-A European Journal  2011, 17, 286-296

 

- Salomone, A.; Petrera, M.; Coppi, D.; Perna, F.M.; Florio, S.; Capriati, V.

Synthesis of Conjugated Tri(hetero)aryl Derivatives Based on One-Pot Double Suzuki-Miyaura Couplings Using Bifunctional Dipotassium Phenylene-1,4-Bis(Trifluoroborate)

Synlett 2011, 12, 1761-1765

 

- Florio, S. 

Unraveling the Synthetic Utility of the Regio- and Stereoselective Lithiation of Aziridines

Synthesis 2012, 44, 2872-2884

- Mansueto, R.; Perna, F. M; Salomone, A.; Florio, S.; Capriati, V.

Dynamic resolution of lithiated ortho-trifluoromethyl styrene oxide and the effect of chiral diamines on the barrier to enantiomerisation

Chemical Communications 2013, 49, 4911-4913

- Florio, S.

alpha-Lithiated alpha-Heterosubstituted 2-Alkyloxazolines: Key Players in Organic Synthesis

Synlett  2013,  24,  1061

 

 

 

 

 

 

 

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